The Expo will be located on a 1.1 million sqm site north-west of Milan comprising part of the municipal territory of Pero and Rho.
In the first half of the last century, part of this area was occupied by manufacturing industries, while the remaining farm land was gradually occupied by shipping warehouses and municipal services.
The realisation of the new Fiera Milano exhibition complex, with architectural design by Massimiliano Fuksas, is of such outstanding quality and economic importance that it has led to the transformation and regeneration of the entire area. Many pre-existing facilities have closed or relocated and former agricultural land has been redeveloped. The specific location has produced an extremely rich and integrated infrastructure:
- The metro Line 1 connects the site to the city's public transportation network, the Molino Dorino parking facilities and a new car park planned at the Fairgrounds;
- The area is served by three motorways—the A4 Turin-Milan-Venice, the A8/A9 Milan-Como-Chiasso, and the Milan-Varese—plus the western orbital road which connects to the A1 Milan-Rome-Naples motorway to the south. These routes are supplemented by access roads which separate local traffic from that transiting to and from the Expo site;
- A station near the east entrance to the complex will provide access to high-speed rail and to two local railway lines connecting to the Milan metro;
- The site's geographical location, equidistant from Linate, Malpensa and Orio al Serio, ensures rapid access to Milan's three airports.
Regarding natural beauty and recreation areas, the site is close to many parks: Parco delle Groane, WWF Vanzago Oasis, Parco Sud and Parco dei Fontanili, Parco delle cave, Parco di Trenno, Monte Stella and the San Siro stadium and sports facilities.
Visitors interested in historic houses will find countless mansions, villas and palaces scattered throughout the province of Milan, including prestigious but little known treasures such as the castles at Rho and Bollate and the stately homes of the Litta family in Lainate, the Valera in Arese and the Burba in Rho.
Finally, there are trips to Lakes Maggiore, Como, Lugano and Varese, areas of outstanding natural beauty and cultural interest linked to the Expo experience via a series of parallel events (e.g., Villa Erba at Cernobbio).